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NDB ID: 7N2M    PDB ID: 7N2M 


Title:

CRYSTAL STRUCTURE OF DNA POLYMERASE ALPHA CATALYTIC CORE IN COMPLEX WITH DCTP AND TEMPLATE/PRIMER HAVING T-C MISMATCH AT THE POST-INSERTION SITE

Molecular Description:

Deposited:

2021-05-29

Released:

2022-04-20

Structural Keywords:

DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Baranovskiy, A.G., Babayeva, N.D., Lisova, A.E., Morstadt, L.M., Tahirov, T.H.
Structural and functional insight into mismatch extension by human DNA polymerase alpha. 
Proc.Natl.Acad.Sci.USA, 119, pp. e2111744119 - e2111744119, 2022.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 140.285   b = 140.285   c = 181.066 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 45573 reflections in the resolution range 44.51 to 2.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)