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NDB ID: 7TXC    PDB ID: 7TXC 


Title:

HIC2 ZINC FINGER DOMAIN IN COMPLEX WITH THE DNA BINDING MOTIF-2 OF THE BCL11A ENHANCER

Molecular Description:

Deposited:

2022-02-08

Released:

2022-06-01

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Huang, P., Peslak, S.A., Ren, R., Khandros, E., Qin, K., Keller, C.A., Giardine, B., Bell, H.W., Lan, X., Sharma, M., Horton, J.R., Abdulmalik, O., Chou, S.T., Shi, J., Crossley, M., Hardison, R.C., Cheng, X., Blobel, G.A.
HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription
Nat.Genet., , pp. - , 2022.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 31 2 1

Cell Constants:

a = 114.237   b = 114.237   c = 59.146 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1934 for 16251 reflections in the resolution range 37.94 to 3.04 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)