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NDB ID: 7WKV    PDB ID: 7WKV 


Title:

CRYSTAL STRUCTURE OF HUMAN ALKBH5 IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND M6A-CONTAINING SSRNA

Molecular Description:

Deposited:

2022-01-11

Released:

2022-03-30

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Kaur, S., Tam, N.Y., McDonough, M.A., Schofield, C.J., Aik, W.S.
Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. 
Nucleic Acids Res., 50, pp. 4148 - 4160, 2022.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32

Cell Constants:

a = 78.364   b = 78.364   c = 106.688 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1929 for 42646 reflections in the resolution range 57.26 to 2.1 Ångstroms with Fobs >  78.99 sigma(Fobs) and with I >  0.0 sigma(I)