NDB ID: 7Z42 PDB ID: 7Z42 
Title:
INFLUENZA B POLYMERASE WITH POL II PSER5 CTD PEPTIDE MIMIC BOUND IN SITE 2B
Molecular Description:
Deposited:
2022-03-03
Released:
2022-05-18
Structural Keywords:
RH DOUBLE HELIX
Nucleic Acid Sequence:
Click to show/hide 1 nucleic acid sequences
Protein Sequence:
Click to show/hide 4 protein sequences
Chain A,D
GSHHHHHHHHGSGSMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVISDMNFLDEEGKAYTALEG QGKEQNLRP
QYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELM IFSYNQDYSLSNESSLDE
EGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQTISRLRDISVPAGFSNFEGM RSYIDNIDPKGAIERNLARMSPLVSVT
PKKLTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLA KECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRD
CVNTISNEEMSNELQKTNYAKWATGDGLTYQKIMKEVAIDDETM CQEEPKIPNKCRVAAWVQTEMNLLSTLTSKRALDLPEIGPDVAPV
EHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLL NESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDVVTVVTFE
FSSTDPRVDSGKWPKYTVFRIGSLFV SGREKSVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRV
NSPKTFSIGTQEGKLVK GSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQ
SAYWFNEW LGFEKEGSKVLESVDEIMDEGSGSGENLYFQ
Chain C,F
GSGSGSGSGMTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMKWAMCSNFPLALTKGDMANRIP LEYKGIQLK
TNAEDIGTKGQMCSIAAVTWWNTYGPIGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNP LTKEMPPDEASNVIMEIL
FPKEAGIPRESTWIHRELIKEKREKLKGTMITPIVLAYMLERELVARRRFLPVAGATSAEFI EMLHCLQGENWRQIYHPGGNKLTESRS
QSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSCLAAIDGGDVACD IIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEIL
IGNGTIQKIGIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSA KKEDMRDLIILCMVFSQDTRMFQGVRGEINFLNRAGQLLSPMYQL
QRYFLNRSNDLFDQWGYEESPKASELHGINESMNA SDYTLKGVVVTRNVIDDFSSTETEKVSITKNLSLIKRTGEVIMGANDVSELESQ
AQLMITYDTPKMWEMGTTKELVQNTY QWVLKNLVTLKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEVMKTDQ
FIKLLPFCFSPPKLRSN GEPYQFLKLVLKGGGENFIEVRKGSPLFSYNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFLVSGK
YDPDLGDF KTIEELEKLKPGEKANILLYQGKPVKVVKRKRYSALSNDISQGIKRQRMTVESMGWALSGWSHPQFEKGSGSENLYFQ
Chain B,E
GSGSGSGSGMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYSNKGKQYISDVTGCTMVDPTNG PLPEDNEPS
AYAQLDCVLEALDRMDEEHPGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSFR LNDLNGADKGGLIPFCQD
IIDSLDRPEMTFFSVKNIKKKLPAKNRKGFLIKRIPMKVKDKITKVEYIKRALSLNTMTKDA ERGKLKRRAIATAGIQIRGFVLVVENL
AKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDNTKWNE CLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNK
IARLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKK LKPFFNEEGTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYL
WDGLQSSDDFALFVNAKDEETCMEGINDFYRTCKL LGINMSKKKSYCNETGMFEFTSMFYRDGFVSNFAMELPSFGVAGVNESADMAIG
MTIIKNNMINNGMGPATAQTAIQLFI ADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHIPEIVLKYNL
MDPEYKGRLLHPQNPFV GHLSIEGIKEADITPAHGPVKKMDYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSAS
YRKPVGQH SMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEIGYIGSGSGENLYFQ
Chain Y,G,X,I
YSPT(SEP)PSYSPT(SEP)PSYSPT(SEP)PSYSPT(SEP)PS
Primary Citation:
Krischuns, T., Isel, C., Drncova, P., Lukarska, M., Pflug, A., Paisant, S., Navratil, V., Cusack, S., Naffakh, N.
Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. 
Plos Pathog., 18, pp. e1010328 - e1010328, 2022.
Experimental Information:
X-RAY DIFFRACTION
Space Group:
P 1 21 1
Cell Constants:
a = 130.93 b = 202.269 c = 135.733 (Ångstroms)
α = 90.0 β = 110.538 γ = 90.0 (degrees)
Refinement:
The structure was refined using the REFMAC program.
The R value is 0.0 for 154519 reflections in
the resolution range 127.106 to 2.418 Ångstroms
with Fobs > 0.0 sigma(Fobs) and with I > 0.0 sigma(I)